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Scientists Identify the Youngest Reported Case of Alzheimer's Disease

By: April Carson



Neurologists at a memory clinic in China have diagnosed a 19-year-old with a condition they believe to be Alzheimer's disease, making him the youngest person in the world to receive such a diagnosis. This groundbreaking discovery sheds light on the early onset of this debilitating condition, highlighting the need for further research and understanding in the field of neurology.


From the age of 17, the young man started to notice a decline in his memory. Unfortunately, as time went on, the cognitive losses only intensified, casting a shadow over his mental faculties. This prompted the man to seek help from a neurologist who, after conducting various tests and imaging scans of his brain, was able to diagnose him with Alzheimer's disease.


Imaging of the patient's brain showed shrinkage in the hippocampus, which is involved in The of his memory and cerebrospinal fluid revealing indications of shared markers associated with this prevalent form of dementia.


Alzheimer's disease (AD) is commonly associated with older individuals, but it's important to note that early-onset cases, which encompass patients under the age of 65, make up approximately 10 percent of all diagnoses. This highlights the significance of acknowledging the prevalence of AD across different age groups.


Pathological gene mutations can account for the development of Alzheimer's in nearly all patients under 30 years old, placing them in the category of familial Alzheimer's disease (FAD). The earlier the diagnosis, the higher the likelihood of an inherited faulty gene being the cause.


However, during their comprehensive search across the genome, the researchers at Capital Medical University in Beijing were unable to identify the typical mutations associated with early-onset memory loss, nor did they find any genes of interest. As a result, the patient is likely to be diagnosed with nonfamilial Alzheimer's disease (NFAD), which tends to affect those aged 40 or over.


Before this diagnosis in China, the youngest individual with Alzheimer's was merely 21 years old. This patient harbored the PSEN1 gene mutation, which triggers the accumulation of abnormal proteins in the brain, giving rise to the formation of toxic plaques - a prevailing characteristic of Alzheimer's disease.


Cases like this recent one in China present somewhat of an enigma. The absence of any history of Alzheimer's or dementia in the 19-year-old's family makes it challenging to classify it as familial Alzheimer's disease (FAD). Moreover, the teenager exhibited no signs of other diseases, infections, or head trauma that could account for his sudden cognitive decline. This perplexing situation leaves medical professionals searching for answers, as they strive to unravel the underlying cause behind this baffling occurrence.


The teenage patient faced challenges with a focus in class two years before their referral to the memory clinic. Additionally, reading became arduous and their short-term memory started to decline. They frequently experienced difficulty recalling events from the previous day and consistently misplaced their belongings.


In the end, the young man's cognitive decline reached a point where he was unable to complete high school, despite his ability to maintain independent living.

To ensure a reliable diagnosis, doctors at the memory clinic administered several tests to evaluate their patient's cognition. Ultimately, the results indicated that his symptoms conformed with those associated with early-onset Alzheimer’s disease.

One after his referral to the memory clinic, he exhibited impairments in immediate recall, recall after a short delay of three minutes, and recall after a long delay of 30 minutes.


The patient's comprehensive memory score was significantly lower, with a decline of 82 percent compared to peers of the same age. Similarly, his immediate memory score showed a substantial decrease of 87 percent.


The young man remains stable on a combination of medications, which includes donepezil and rivastigmine. He also attends speech therapy sessions multiple times per week to preserve what cognitive functions he has left.


A comprehensive long-term follow-up is necessary to corroborate the young man's diagnosis. Remarkably, the patient's medical team emphasized that he is reshaping our comprehension of the conventional age at which AD manifests.


According to a study conducted by neurologist Jianping Jia and colleagues, the patient exhibited signs of early-onset AD without any identifiable pathogenic mutations. This finding implies that further exploration is needed to understand the underlying mechanisms of the disease.


This groundbreaking case of Alzheimer's in such a young person is expected to spark intense research into the causes and effects of early-onset Alzheimer’s. As scientists further explore this topic, they may be able to develop improved methods for managing dementia, particularly at the earliest stages of manifestation. In addition, there may be potential opportunities for preventive strategies that could help safeguard against memory loss in older adults.


The research findings were recently published in the esteemed Journal of Alzheimer's Disease.











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April Carson is the daughter of Billy Carson. She received her bachelor's degree in Social Sciences from Jacksonville University, where she was also on the Women's Basketball team. She now has a successful clothing company that specializes in organic baby clothes and other items. Take a look at their most popular fall fashions on bossbabymav.com


To read more of April's blogs, check out her website! She publishes new blogs on a daily basis, including the most helpful mommy advice and baby care tips! Follow on IG @bossbabymav


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